Spirit and matter are completely contradictory things. All of us are spiritual entities. We cannot have perfect happiness, which is our birthright, however much we may meddle with the affairs of mundane things. Perfect happiness can be ours only when we are restored to our natural state of spiritual existence.
Anyone who has developed the ecstasy of love for the Supreme Personality of Godhead and who is always merged in transcendental bliss on account of that love, cannot even perceive the material happiness or distress coming from the body or mind.
From association with devotees is born faith. From faith is born pure knowledge. From pure knowledge is born meditation. From meditation is born devotional service, which pleases Lord Krishna and destroys all sufferings.
Within the heart of a person overpowered by lamentation or anger, there is no possibility of Krishna being manifest.