Nobody is free from anxiety. The soul is suffering & that is expressed through the manifested body.
A bonafide devotee of Lord Krishna is always pained to see the fallen condition of the whole world. Srila Bhakti Siddhanta Sarasvati Thakura used to say, "There is no scarcity of anything within this world, the only scarcity is of Krishna Consciousness." That is the vision of all the pure devotees. Because of this lack of Krishna Consciousness in human society, people are suffering terribly, being maerged in an ocean of nescience and sense gratification. A devotee onlooker is very much aggrieved to see such a situation in the world. — Sri Chaitanya Caritamrita, Adi Lila, Chapter 13, Text 67.
When we will think deeply, then we will realize that enjoyment is short lasting and reality of it is suffering.
Even in the womb of the mother you will suffer. To remain in that compact bag for so many months, hands and legs all tied up, unable to move this is suffering. So we should be intelligent enough to ask, "Why am I suffering? and how can I stop this suffering?"
The sufferings of humanity are due to forgetfulness of Krishna as the supreme enjoyer, the supreme proprietor and the supreme friend. Therefore, to act to revive this consciousness within the entire human society is the highest welfare work. One cannot be engaged in such first-class welfare work without being liberated.
The flip side of happiness is suffering.