We are like fish out of water. Just as a fish cannot be happy unless he is in the water, we cannot be happy apart from the spiritual world.
Without the grace of the Lord, no one can become happy and prosperous.
Srimad Bhagavatam 3.1.26,
The more we are happy in Krishna Consciousness the more we become purified.
Actual joy is a product of the spiritual nature. It spontaneously manifests when the living entity begins to love God.
That procedure which in the beginning may be just like poison but at the end is just like nectar and which awakens one to self-realization is said to be happiness in the mode of goodness.