Bhagavatam should be heard by dhiras, who have controlled their minds & senses.
1st and 2nd canto (of Srimad Bhagavatam) are the most important. These are the Foundational Things.
By hearing Srimad Bhagavatam, one will be able to understand what is the final duty, the ultimate duty that must be performed especially at the moment of death.
Spiritual rasas [tastes], which are relished even in the liberated stage, can be experienced in the literature of the Srimad Bhagavatam due to it being the ripened fruit of all Vedic knowledge. By submissively hearing this transcendental literature, one can attain the full pleasure of his heart's desire.
Srimad Bhagavatam is the topmost theological science and therefore it can react on the laymen as medical doses. There is no difference between the lord and Srimad Bhagavatam.
Srimad Bhagavatam begins with the surrender of the devotee unto the Absolute Person. The devotee is fully aware that he is one with the Absolute and at the same time he is in the eternal position of servant to the Absolute.