Determination means to serve Krishna inspite of bodily inconveniences.
To serve Krishna means life and to engage in sense gratification means death.
We should always remember that our body is not for sense gratification, it is for Krishna’s service only. To render very good service to Krishna we should not neglect the upkeep of the body.
A musician, because one has got a good attachment for music, he tries to perform it very perfectly. So love is the basis. Similarly, when you serve Krishna, if you have no love for Krishna, you cannot serve Him very nicely. Krishna also does not accept your service if it is not done in great love and affection.
Even the worms, birds and beasts are assured of elevation to the highest perfected life if they are completely surrendered to the transcendental loving service of the Lord, so what to speak of the philosophers among the human beings.
Reject all other desires, abandon philosophical speculation and fruitive work and refrain from the worship of the demigods and demigoddesses. Just worship and serve Lord Krishna with your body and mind in the company of other devotees.